Common medications, foods, and beverages can disrupt the integrity of our intestinal barrier, causing leaky gut.
Intestinal permeability, leakage of our intestine, can occur Happen A new target for both disease prevention and treatment. With all its little layers, our intestinal barrier covers a surface of more than 4,000 square feet – that’s bigger than a tennis court – and requires about 40% of our body’s total energy expenditure to maintain it.
Evidence of this is increasing trapped “Disruption of intestinal barrier integrity” has been implicated in the development of several conditions, including celiac disease and inflammatory bowel disease. The researchers measured intestinal permeability using blue food coloring. It persisted in the intestines of healthy participants but was found in the blood of extremely ill patients suffering from sepsis with damaged intestinal obstruction. However, you don’t need to go to the ICU for leaky gut. Simply taking some aspirin or ibuprofen may do the trick.
In fact, taking Taking two regular aspirin (325 mg tablets) or two extra strength aspirin (500 mg tablets) just once can increase leakiness in our gut. These results suggest that even healthy people should be cautious when using aspirin, as it can cause gastrointestinal obstruction.
What about buffered aspirin, an aspirin-antacid combination that theoretically “buffers” gastrointestinal irritation? Apparently it doesn’t matter: both regular aspirin and bufferin Production Multiple erosions in the inner lining of the stomach and intestine. Researchers inserted a scope into people’s throats and saw extensive erosion and redness inside in 90% of those who took aspirin or bufferin at recommended doses. how many hours is it Take As for the damage caused? nobody. This can happen in just five minutes. acetaminophen, sold Tylenol, as sold in the United States, may not cause gastrointestinal damage and may be a better choice, unless you have problems with your liver. And instead of making things better, vitamin C supplements appeared To make the aspirin-induced increase in leaky gut worse.
Interestingly, this is probably why NSAID drugs like aspirin, ibuprofen, and naproxen Involved Food-induced anaphylaxis occurs in up to 25%.” In other words, they are associated with a 10 times greater chance of life-threatening food allergy attacks, possibly because these drugs increase intestinal barrier leakage, allowing small food particles to slip into the bloodstream. But could exercise also increase the risk?
Vigorous exercise—for example, an hour at 70% maximum capacity—may divert So much blood gets carried away into the muscles and to our internal organs that it can cause transient injury to our intestines, causing mild leaky gut. but this can happen very bad If athletes take ibuprofen or any other NSAID medications, which is unfortunately very common.
can also drink alcohol Happen This is why a risk factor for food allergy attacks is increased leaky gut. But Cutting Take out the alcohol, and our intestines can heal.
What other dietary components can do Make a difference? Increased consumption of saturated fats, which are found in meat, dairy and junk foods, can cause the growth of bad bacteria that produce the rotten egg gas hydrogen sulfide, which can degrade the protective mucus layer. You can see the process below and in my video at 3:21 Avoid these foods to prevent leaky gut.
it is Said To be clear, high-fat diets generally have negative effects on intestinal health “by disrupting the intestinal barrier system through various mechanisms,” but most of the studies citing negative effects were conducted in laboratory animals or petri dishes. Are people also affected in the same way? You won’t know for sure until you test it.
Rates of obesity and other cardiometabolic disorders have increased increased There is a rapid transition from traditional low-fat diets to high-fat diets. We know that disruptions in our good gut flora have been shown to be linked to a higher risk of many of these same diseases, and studies using rodents show that a high-fat diet “unbalances” the microbiome by impairing the gut barrier, resulting in disease. However, to connect all the dots, we need a human intervention trial – and we got one: a six-month randomized controlled-diet trial on the effects of dietary fat on gut microbiota. It found that, in fact, high fat consumption was associated with adverse changes in the gut microbiome and proinflammatory factors in the blood. Note that it also wasn’t primarily saturated fat like meat and dairy. The researchers replaced refined carbohydrates with refined fats – substituting white rice and wheat flour for soybean oil. These findings suggest that countries that are Westernizing their diets should be advised against increasing dietary fat intake, while countries that have already adopted such diets should consider reducing.
doctor’s note
For more information on leaky gut see The Leaky Gut Theory of Why Animal Products Cause Bloating And How to cure leaky gut with diet.
I also talked about leaky gut in my SIBO video: Friday Favorites: Testing for Small Intestine Bacterial Overgrowth (SIBO), Fiber and Low FODMAP.
